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BELVIQ (Lorcaserin Hydrochloride) adalah agonis reseptor 2C serotonin untuk pemberian oral yang digunakan untuk manajemen berat badan kronis. Nama kimianya adalah (R) -8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3- benzazepine hydrochloride hemihydrate. Formula eksperimental adalah C11H15Cl2N • 0.5H2O, dan berat molekul bentuk hemhyydrate adalah 241.16 g / mol. Rumus struktural adalah:
Ilustrasi gambar struktural BELVIQ (Lorcaserin Hydrochloride)
Lorcaserin hemihydrate hydrochloride adalah serbuk putih ke putih dengan kelarutan dalam air lebih besar dari 400 mg / ml. Setiap tablet BELVIQ mengandung 10,4 mg lorcaserin crystalline hydrochloride, setara dengan 10,0 mg lorcaserin hidroklorida anhidrat, dan bahan-bahan tidak aktif berikut: selulosa mikrokristalin selulosa, hidroksipropil selulosa NF; natrium croscarmellose NF. Silikon dioksida koloid NF, USP polivinil alkohol, NF polietilen glikol, USP titanium dioksida, bedak USP, aluminium danau FD&C Blue # 2, dan NF stearat magnesium.
Indikasi untuk digunakan
BELVIQ diindikasikan sebagai tambahan untuk diet rendah kalori dan peningkatan aktivitas fisik untuk manajemen berat badan kronis pada pasien dewasa dengan indeks massa tubuh primer (BMI) dari:
30 kg / m² atau lebih tinggi (obesitas), atau
27 kg / m² atau lebih (penambahan berat badan) dengan setidaknya satu penyakit terkait berat badan (misalnya, tekanan darah tinggi, dislipidemia, diabetes tipe 2) (lihat Dosis dan Administrasi)
Batas penggunaan
Keamanan dan keefektifan administrasi gabungan BELVIQ dengan produk penurun berat badan lainnya belum terbukti termasuk obat yang diresepkan (seperti phentermine), obat bebas, dan persiapan herbal.
Efek BELVIQ pada morbiditas dan mortalitas kardiovaskular belum terbukti
Tag :
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Lorcaserin - › wiki › Lorcaserin
Lorcaserin, marketed under the brand name Belviq and previously Lorqess during development, is a weight-loss drug developed by Arena Pharmaceuticals.
Trade names: Belviq Pregnancy category: US: X (Contraindicated):
Other names: APD-356 CAS Number:
Side effects · Mechanism of action · Approval history
Lorcaserin Uses, Side Effects & Warnings - › Drugs A to Z › Lorcaserin
4 Nov 2019 - Physician reviewed lorcaserin patient information - includes lorcaserin description, dosage and directions.
Lorcaserin: MedlinePlus › druginfo › meds
Lorcaserin: learn about side effects, dosage, special precautions, and more on MedlinePlus.
Belviq (Lorcaserin Hydrochloride): Uses, Dosage, Side Effects ... › belviq-drug
BELVIQ (lorcaserin hydrochloride) Tablets. BELVIQ (lorcaserin hydrochloride) is a serotonin 2C receptor agonist for oral administration used for chronic weight ...
harga obat belviq
phentermine
Lorcaserin | C11H14ClN - › compound › L...
Lorcaserin is a selective serotonin agonist that is approved as a weight loss agent. Lorcaserin has been in clinical use for a short time only, but has not been ...
PubChem CID: 11658860 Molecular Weight: 195.69 g/mol
Molecular Formula: C11H14ClN
Lorcaserin (Belviq) Withdrawn From US Market Due to Cancer ... › viewart
4 hari yang lalu - The Food and Drug Administration asked Eisai to voluntary withdraw the weight-loss drug lorcaserin (Belviq and Belviq XR) on Feb. 13 after a ...
Belviq, Belviq XR (lorcaserin) dosing, indications, interactions ... › drug › belviq-bel...
Medscape - Obesity dosing for Belviq, Belviq XR (lorcaserin), frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy ...
Belviq, Belviq XR (lorcaserin) by Eisai: Drug Safety ... - › safety › belviq-belviq-xr-lor...
5 hari yang lalu - ISSUE: FDA has requested that the manufacturer of Belviq, Belviq XR (lorcaserin) voluntarily withdraw the weight-loss drug from the U.S. ...
Belviq, Belviq XR (lorcaserin): Drug Safety Communication ...› belviq-belviq-xr-lor...
14 Jan 2020 - At this time, the cause of the cancer is uncertain, and we cannot conclude that lorcaserin contributes to the cancer risk. However, we wanted to ...
CV Safety Trial for Lorcaserin Picks Up Cancer Signal: FDA ... › news › cv-safety-trial-lorc...
14 Jan 2020 - Lorcaserin, a selective agonist of the 5-hydroxytryptamine 2C serotonin receptor, was approved in 2012 as a weight-loss drug to be used in ...